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Formulation strategies that extend nasal residence time or enhance epithelial transport may also facilitate dose reduction while preserving therapeutic efficacy (Illum, 2003

Cellular sensitivity in response to NO, its exposure period and concentration and the activity of different NOS isoforms along with their localization appear to influence NOs actions in malignancies

Selenium is an important antioxidant that helps the body produce and recycle glutathione

Experimental investigations suggest that modulation of NNMT activity may influence cellular pathways associated with energy utilization, nutrient partitioning, and metabolic adaptation