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Gertz MA

In the upper small intestine where the pH changes to less acidic conditions, haptocorrin is degraded by pancreatic proteases, releasing B12 which subsequently becomes bound to gastric intrinsic factor (IF) to form the IFB12 complex

The modification at its N-terminal region appears to prolong its activity, while also maintaining a resemblance to the physiological patterns of GHRH action

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