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Recent findings indicate that cholesterol accumulation within mitochondria sensitizes hepatocytes to OxE and apoptotic signals, exacerbating liver damage in MASLD

Therefore, icariin and icaritin promote the infiltration of immune cells, inhibit various immune checkpoints, reduce the levels of inflammatory cytokines and enhance anti-cancer immunity

J Agric Food Chem 56:90649071

These data pointed to the possibility that the cooperative engagement of CRBN might depend on contacts made outside of the 10 radius included in the DMS screen