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Autologous transplantation of CD34 + hematopoietic stem and progenitor cells transduced with BB305 lentiviral vector encoding beta AT87Q -globin gene was reported to eliminate the need for blood transfusion in 91% of children and adults 50 years old with TDT and nonbeta 0 /beta 0 genotype (185)

It is well-known that the enhanced glycolytic pathways favor the induction of M polarization toward M1-type M (238), as well as the production of various inflammatory cytokines, including IFN- and TNF-

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