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Another aspect of barrier function is related to the functioning of multiple active transporters, which carry nutrients and metabolites in both directions ( A second interface between the CNS and periphery, formed by the epithelial cells of the choroid plexus facing the CSF, the CSF per se , and the highly permeable ependyma in the brain ventricles, constitute the BCB (Spector et al., 2015)

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This hypothesis is supported by the causal mediation analysis, suggesting a causal role of HPA-axis function on changes of redox homeostasis in females