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A list of primer sequences for different genes used in the qPCR study is provided in Supplementary information (Table S1)

Compared with -glucuronidase-based systems, -galactosidase-cleavable linkers are generally considered to favor intracellular activation, offering a release profile that may enable more controlled drug liberation with reduced reliance on extracellular bystander effects

In South Korea it is 12 per 100,000 inhabitants [12], while it is higher in China with an estimated incidence of 24 per 100,000 [13]

To investigate their biogenesis, we perform cryo-electron microscopy and liposome tubulation assays, showing that Arabidopsis SNX1 generates shorter membrane tubules than its mammalian counterpart, consistent with reduced membrane affinity linked to differences in the amphipathic helix