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The activities of SOD, CAT, and APX scavenge ROS, which otherwise cause oxidative damage, and then convert them to harmless H 2 O and O 2 (Shekhawat et al., 2010)

doi: 10.1002/advs.201903035

2-oxoglutarate, a product of the catabolic reaction of the NADP-GDH and an intermediate of the TCA cycle, inhibits the binding of GdhR to gdhA P2 (Pagliarulo et al., 2004)

But my perspective is, look, everyone should always go for the low hanging fruit first and then, you know, start taking a crack at the deeper, more idiosyncratic things when you run it, when you hit a wall