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Early clinical trials have demonstrated the safety and efficacy of CD19-targeted CAR-T cell therapy in various other autoimmune diseases including systemic lupus erythematosus for which this treatment approach appears to be more effective compared with other B cell depleting agents like rituximab [45]

J Rheumatol Supplement 96:3135 Cruz LF, de Figueiredo GF, Pedro LP, Amorin YM, Andrade JT, Passos TF, Rodrigues FF, Souza ILA, Gonalves TPR, dos Santos Lima LAR (2020) Umbelliferone (7-hydroxycoumarin): a non-toxic antidiarrheal and antiulcerogenic coumarin

These findings suggest that enhancing PCBP1 activity may become a potential new direction for the treatment of DR

In individuals with A1AT deficiency, with Z and S polymorphisms, there is a significant accumulation of iron in the liver (61)