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4.1.14 SIAH2 SIAH2 (Seven in Absentia 2) is a RING-type E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of REV-ERB and REB-ERB, two core repressors in the circadian clock ( SIAH2 deletion modestly affects expression of other clock genes such as BMAL1 and PER2 but does not significantly alter REV-ERB protein rhythms, likely due to compensatory E3 ligases (Mekbib et al., 2022)