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Likewise, the small GTPases required for TNT formation are central regulators of cell morphology, adhesion dynamics, migration, and phagocytosis, and excessive inhibition could compromise tissue homeostasis or impair immune responses [583]

Furthermore, glutamine-derived fumarate, malate, and citrate are significantly increased when glucose is deprived, demonstrating that glutamine drives the glucose-independent TCA cycle in a nutrient-poor tumor microenvironment (Le et al., 2012)

In this study, cigarette smoking was associated with serum uric acid levels, hyperuricemia, and gout only in females, indicating that sex acts as an effect modifier