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World J Cardiol

Given that both ME/CFS patients and GWS models exhibit elevated levels of oxidative stress, the symptom improvement observed with oxaloacetate treatment may be attributable to its capacity to reduce oxidative stress (Gottschalk et al., 2022

Winner et al., 2011)

Therapeutic intervention may involve the use of renin-angiotensin system (RAS) blockers to inhibit the vasoconstrictive effect of angiotensin II at the vas efferens or sodium-glucose co-transporter-2 (SGLT2) inhibitors, constricting the afferent arteriole, thereby reducing the burden of excessively filtered molecules in the proximal tubule (e.g., albumin, glucose and phosphate) [34]