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It is to be understood that the words which have been used are words of description rather than limitation, and that changes may be made within the purview of the appended claims without departing from the true scope and spirit of the disclosure in its broader aspects

doi: 10.1016/j.pbiomolbio.2020.04.001 78 PhaniendraAJestadiDBPeriyasamyL

Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase, can cross the blood-brain barrier, activating P126 and mitochondrial ROS production, restoring normal mitochondrial function in 53 out of 125 gliomas patients [81, 216, 217]