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For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]

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Forty-six patients were randomly separated into ALA group, which received 1200 mg ALA or placebo group, which received placebo per day for 12 weeks

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