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[3] Chang CH, Tsai WC, Hsu YH, Pang JH

The pale yellow keratin of non-pigmented hair appears white due to light refraction or reflection.34 Compared with pigmented hair, gray hair is thicker, stiffer, and more difficult to manage, grows faster, and is more susceptible to UV radiation damage, requiring greater protection.35 Alterations in hair fiber make it more difficult to maintain artificial color, leading many individuals to undergo repeated dyeing procedures, which may result in toxicity from artificial hair dyes.36 There are no sex-related differences in the prevalence of premature graying.37 In women, gray hair usually begins along the hairline, whereas in men it typically starts in the temporal region and sideburns

[2] Ketamine may be especially useful in buprenorphine-induced opioid withdrawal (e.g., at pain doses such as 0.2-0.3 mg/kg)

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