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Found in the pituitary gland in vertebrates including humans, -MSH is a melanocortin receptor agonist that contributes to several physiological processes, including melanogenesis, appetite modulation, and sexual desire

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After ADC internalization via receptor-mediated endocytosis, the conjugates are transported to acidic organelles such as endosomes and lysosomes, where pH values typically range from 4.5 to 6.0

Therefore, aside from the thrombectomy process, nanomaterial-assisted strategies for vascular structural reconstruction and long-term stability should not be overlooked