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[DOI] [PubMed] [Google Scholar] Sher M.R., Steven G.C., Romett J.L., Pien G., LeBenger K., Messina J.C., et al

Copper overload can lead to excessive ROS accumulation, enhance myeloperoxidase activity and activate the NF-B signaling pathway, promoting the release of pro-inflammatory cytokines (such as IL-1 and TNF-) while inhibiting anti-inflammatory cytokines, resulting in a chronic inflammatory state (132,133)