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7 Conclusions and perspectives In recent years, with the increasing exploration of the intestinal microenvironment, there is growing evidence that dysbiosis of the gut microbiota and disorders of iron metabolism are closely associated with the onset and progression of IBD

Research demonstrates that high glucose activates NADPH oxidase within podocytes, triggering excessive ROS production, which subsequently initiates oxidative stress and mitochondrial dysfunction, ultimately leading to podocyte apoptosis and foot process effacement (Yasuda et al., 2021)

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