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Of particular importance are the colonic microbial metaboliteslow-molecular-weight phenolic derivatives generated via gut microbiotawhich have recently attracted attention for their potential role in modulating inflammation ( Moreover, considerable interindividual variability in EC metabolism exists, predominantly driven by differences in gut microbiota composition and host enzymatic profiles ( To bridge these critical knowledge gaps, this review systematically explores the anti-inflammatory mechanisms of EC, emphasizing the interplay between its structural properties, metabolic fate, and the bioactivities of its microbial metabolites

Autophagy 17:15611562

EGCG downregulates M1 markers (IL-6, TNF-, and IL-1) and upregulates M2 markers (IL-10 and NQO1) in microglia, thereby modulating the M1/M2 ratio and mitigating neurotoxicity and neuronal damage arising from microglial hyperactivity (13)