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The most important biological function of L-CN is the transport of fatty acids into mitochondria for -oxidation 38 , which leads to esterification of L-CN to form acylcarnitine derivatives 39,40 , whereas L-CN can catalyze the synthesis of l-palmitoylcarnitine by palmitoyl coenzyme A 41

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Well-established agents with favorable safety profiles, such as azathioprine and upadacitinib, represent viable candidates for CD treatment