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A trained clinician does this routinely

However, from the very few biohackers who have put their lives on the line to experiment with this peptide, heres what has been reported so far Burning/itching at site of injection (here, here, and here) Fatigue Nausea Muscle soreness Vital biomarkers must be consistently tracked to gauge effectiveness of FOXO4-DRI (blood and urine tests, DNA methylation tests, medical scans, etc.) Longecity user Vantika advises to NOT take FOXO4-DRI with compounds such as Rapamycin, Quercetin, corticosteroids and cortisol to avoid diminishing its senolytic effects (a 1-2 week washout is what they recommend, possibly five weeks, and nothing shorter than 96 hours) FOXO4-DRI is likely useless for healthy men/women in their 20s/30s (as backed up by Longecity member Rocket here and here) The senolytic ability observed for FOXO4-DRI may prove to be too powerful in humans and have unintended consequences There is also a great deal of suspicion behind the testimonials of biohacker Darren Moore on top of taking multiple supplements simultaneously, he has allegedly failed to show independent proof he is taking 100% pure FOXO4-DRI

Semaglutide Semaglutide is a GLP-1 receptor agonist

Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y, Guan F (2019) Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/-catenin pathway