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1d) revealed that the isolated protein is characterized by -strands and unfolded segments consistent with its structure in the SLC complex 21 and the presence of an unstructured extension

However, despite these successes, there is an urgent need for a better understanding of the role of Gln in tumor metabolism and therapy resistance depending on the genetic profile of cancer cells and the dynamically changing tumor microenvironment

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Copper has a complex role in oxidative biology participating in both prooxidant chemistry (where free or weakly bound copper can catalyze damaging reactive-oxygen-species generation) and antioxidant chemistry (as the cofactor of Cu/Zn superoxide dismutase)