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Challenges and future aspects Challenges in the experimental tools to study the exact mechanism of HIV-1-related factors on microglial activation Experimental model limitations: many current models fail to replicate the complex microenvironment of the CNS, which often results in incomplete or potentially misleading interpretations of activation mechanisms

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As AI technologies continue to advance, their integration into ADC development will likely result in faster and more efficient design cycles, improving the overall success rate of ADC-based therapies [375, 376]