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3.1 Endothelial dysfunction Various clinical and laboratory studies have shown that endothelial dysfunction induced by cigarette smoke is mediated by decreased nitric oxide (NO) bioavailability, increased production of superoxide anions, and increased production and release of endothelin ( 28 )

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Chain-hitting one in under an hour, especially on an empty stomach, can easily push a lower-tolerance vaper user past the point of toxicity