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Emerging technologies, including brain organoids and microfluidic organ-on-chip platforms, provide enhanced physiological relevance by simulating multicellular brain environments and nutrient flow (Castiglione et al., 2022)

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The combination with Cagrilintide is not studied in the literature and theoretically: Cagrilintide + Tirzepatide would lead to a three-way appetite suppression (GIP + GLP-1 + amylin), potentially supra-additive, but with the risk of strong nausea and loss of muscle mass Cagrilintide + Retatrutide would be a four-way activation, highly speculative For research it is an alternative, not a combination , choose one strategy