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Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure

Indeed, enhancing lysosomal-mediated proteolysis by overexpressing transcription factor EB (TFEB) in neuromelanin-producing rats was shown to reduce the intracellular neuromelanin density, attenuate PD-like inclusion formation, prevent nigrostriatal neurodegeneration, and reverse motor impairment [18]

ArticlePubMed 10

However, from a biochemical and pharmacological perspective, it makes sense to associate these disturbances with a decreased activity of mitochondrial function