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The transcription factor JUND was identified as a key regulator of this subtype, providing a novel therapeutic target [301]

Chronic stress: Elevated cortisol degrades the extracellular matrix around follicles and triggers inflammation, accelerating shedding

Figure 1 Important developments in the field over this time include the first clinical descriptions of the inborn error of metabolism disorder homocystinuria and the subsequent discovery of severe genetic defects in enzymes involved in homocysteine metabolism as causative factors (4)

These two catalytic activities of the enzyme are classified as glycohydrolase and ADPR-ribosyl cyclase [34-35, 38-40, 51, 58-60]