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The presence of copper may be central to these observations, including collagen synthesis, modulation of inflammatory signaling, and antioxidant potential

The alcohol effect is essentially identical

HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium

Switching of modA expression from OFF to ON state within the middle ear produces a phenotypic switch in several genes during infection that increases disease severity and permits bacterial persistence by increasing cell adhesion, invasion and robust biofilm formation ( ModA16 ON state, NTHi upregulates multiple iron-acquisition factors including an iron ABC transporter substrate-binding protein, and haem/haemopexin-binding proteins HxuC and HxuB (Tram et al., 2024)