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Iranian Journal of Nursing and Midwifery Research, 15 (Suppl 1), 401-405

doi: 10.1016/j.phymed.2023.154881 15 WangYZhengLShangZYangTLiFLiuW,et al

Weir, H

Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)