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Not only that, after the small molecule compound Fer-1 inhibited the decrease of glutathione peroxidase 4 (GPX4), the contents of superoxide dismutase (SOD) and glutathione (GSH) increased, malondialdehyde (MDA) decreased, the fluorescence expression of JC-1 polymer increased, the fluorescence of Fe 2+ weakened, and the number of autophagosomes and autolysosomes decreased under transmission electron microscopy.Clear mitochondria and endoplasmic reticulum were observed under high magnification, and the migration and proliferation functions of GC cell lines were also improved.In GC cell lines, ARNTL can activate downstream EGLN2