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Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

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Water (Aqua), Aloe Barbadensis Leaf Juice, SD Alcohol 40-B (Alcohol Denat.), Alanine/Histidine/LysinePolypeptide Copper HCl, Panthenol, Arginine, Lactic Acid, Polyquaternium-16, Butylene Glycol, Biotin, PEG-12 Dimethicone, Glycerin, Pisum Sativum (Pea) Sprout Extract, Lavandula Angustifolia (Lavender) Flower Extract, Camellia Sinensis (Green Tea) Leaf Extract, Scutellaria Baicalensis Root Extract, Propanediol, Menthol, Pinanediol, Camphanediol, Polyquaternium-44, Amodimethicone, Hydrolyzed Quinoa, Coco-Caprylate, Isomalt, Xylitol, Glycine Soja (Soybean) Germ Extract, Triticum Vulgare (Wheat) Germ Extract, Guar Hydroxypropyltrimonium Chloride, Cetrimonium Chloride, Trideceth-12, Phenoxyethanol, Ethylhexylglycerin, Potassium Sorbate, Sodium Benzoate