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Genome-wide Association Study Identifies ABCG2 (BCRP) as an Allopurinol Transporter and a Determinant of Drug Response

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In a mouse model of cerebral ischemia, HCA2 activation by BHB promotes a neuroprotective phenotype of macrophages to produce prostaglandin D2, which exerts neuroprotective effects, suggesting a potential immunomodulatory mechanism that may be relevant in inflammatory contexts [45]

Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model