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This is important because transfusion interval is not just a theoretical marker but a direct measure of disease burden and hospital dependency in daily life

Two powerful therapies

Unfortunately, pain scores were not assessed at any earlier points in this study, it is therefore unknown whether pain had decreased more in the B12 group at an earlier time point

Norethisterone is generally well tolerated but the following side effects tend to be the most common: Bleeding disorders eg Breakthrough bleeding, spotting, amenorrhea Breast tenderness Headache Dizziness, Fatigue Nausea, Vomiting Acne Fluid retention, bloating If you notice any of the symptoms below, discontinue Norethisterone immediately and speak to your doctor or pharmacist