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Such challenges include decreased adherence, feelings of hunger, weight regain, and potential loss of lean mass and bone density (Hofer et al., 2022)

4b), indicating the thiol group was added to the vinylic C 6 in a 1,6-addition reaction

While current clinical and basic evidence strongly supports ferroptosis as a key contributing mechanism in periodontitis progression, the extent of its role relative to classical pathogenic factors such as dysbiosis and immune dysregulation, as well as its causal temporality in the natural history of the disease, remains unclear