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Proc Natl Acad Sci U S A, 1998

Both approaches can work effectively

Patient Comfort: Scientific Reality Specialist practitioners report significantly lower discomfort levels compared to initial tattooing procedures

Common genetic polymorphisms for HNMT might be related to a possible role for individual variation in histamine metabolism in the pathophysiology of diseases such as allergy, asthma, peptic ulcer disease, and some neuropsychiatric illnesses (Preuss et al., 1998)