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It was also reported for its beneficial effect in Phase III clinical trial for type 2 diabetes and stage 4 chronic kidney disease patients, where it was shown to improve the estimated glomerular filtration rate (GFR) ( , a nutritional supplement containing five natural Nrf2 activators such as bacosides, silymarin, withanolides, ECGC and curcumin has been shown to reduce oxidative stress and increase antioxidant enzymes SOD and catalase expression (Nelson et al., 2006)

Adverse Events FDA received an adverse event report on January 14, 2019, regarding seven patients in an outpatient clinic who received intravenous injections containing L-glutathione 200mg/mL compounded by a pharmacy using L-glutathione repackaged by Letco (lot number: 1810150050, expiration date: 6/17/2020)

Always check for original packaging and expiry date to avoid counterfeit products.

It remains prohibited under the 2026 Prohibited List