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Neurotoxicology 90, 102111

Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimers disease

Due to this evidence, some researchers believe that herpesviruses as one of the causes of ME/CFS is a fading hypothesis (150)

That's the kind of long-game thinking that separates people who age well from those who don't and it's exactly the logic behind including B12 in Building Blocks at a dose designed for optimization, not just deficiency avoidance