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Its documented history is unusual among research peptides because it can be read as the pursuit of one narrow scientific question across roughly two decades: whether the fat-related actions of the growth hormone molecule can be uncoupled from its growth-promoting and glucose-related actions

Human-equivalent-dose extrapolation from that protocol lands around 650 mg/day for an 80 kg adult, but no human has been studied at any dose in a published trial

Additionally, niacin has been noted to increase fasting blood glucose by inducing insulin resistance in some cases

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