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This exhaustion is driven by transcription factors such as FOXO1, 488 FOXO3, and TOX and is further reinforced by epigenetic modifications involving DNMT3A, EZH2, and HBO1 489,490 (Fig

Specially, frontotemporal network and brain activity dysfunction in this area has been known to be a target of mTBI which is mainly responsible for cognitive impairment in these patients (57, 58)

4.1.4 Administration routes and formulations In the preclinical studies reviewed, the following administration routes were commonly reported: 4.1.4.1 Oral administration When it comes to administering plant-based metallic nanoparticles in antidiabetic models, this is the most popular method

10.18632/oncotarget.1958 Oncotarget