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Figure 2 was created with BioRender.com

Extracted data from the final selection of articles were then narratively synthesized to delineate the current state of knowledge and identify existing gaps in the literature

Numerous studies have extensively analyzed and documented the implications of its application in PD modeling 6,7,8

Subsequent researches demonstrated that co-culture with MCF-7 and CAFs resulted in promoted glutamine catabolism and inhibited glutamine synthesis in cancer cells, thereby promoting cancer cell growth and progression (274)