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Su clasificacin como inhibidor NNMT lo distingue de precursores del NAD+ y define su papel experimental en la investigacin metablica contempornea

A study (58) assessing the effects of resveratrol on metabolic parameters in ob/ob mice injected daily with resveratrol for 20 days or left untreated (as controls) showed that resveratrol: reduces testosterone reduces insulin levels reduced TNF- and IL-6 levels in adipose tissue In a rat model for PCOS (59), daily intraperitoneal injection of resveratrol for 4 weeks induced: a significant reduction in the number of antral follicle counts a significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (playing a key role in PCOS metabolic disturbances) significantly lower superoxide dismutase activity significantly increased glutathione peroxidase which will reduce cell vulnerability to ROS

2024;S00223166(24):01121

Additionally, an attenuation of the Apoptosis pathway was observed in a mouse model of PSO ( Figure 4B )