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1 Introduction Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation caused by airway and/or alveolar abnormalities resulting from toxic particles or gases ( COPD is known to be associated with reduced diversity of the normal lung microbiota and replacement of resident flora by potentially pathogenic microorganisms ( Bacteroides and Firmicutes ( Proteobacteria ( Firmicutes, Prevotella, and Streptococcus , and a decrease in Bacteroidetes ( Gut and lung microbes interact with each other through the blood or lymphatic system

The first involves modulating the interactions between proteins and monosodium urate molecules or crystal interfaces to disrupt crystallization dynamics and alter crystal surface properties

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