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Arginine metabolism plays a pivotal role through its depletion by arginase-1, which not only limits T cell proliferation but also disrupts nitric oxide signaling and T cell receptor activation [46]

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Muftuoglu M, Li L, Mak DH, Burks JK, Xi Y, Hu B, Shaim H, Imahashi N, Bdaiwi MH, Jimenez JE, Banerjee PP, FLLW I, Kerbauy LN, Kaplan M, DePombo AM, Mendt MC, Basar R, Daher M, Marin D, Andreeff M , Wang J, Wierda WG, Thompson PA, Jain N, Keating MJ, Armstrong-James D, Champlin RE, Shpall EJ, Rezvani K