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64 In serine proteases, neutrophil elastase (NE), cathepsin G and proteinase-3 destroy lung tissue by degrading ECM components, and induces epithelial cells and endothelial cells to release a variety of inflammatory factors to activate and chemoattract neutrophils to produce lung inflammation

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There was a caspase-3 immunopositivity in inflammatory cells of the peribronchial tissue and interalveolar area of the IR group (Fig

Patients received either pemetrexed 500 mg/m2 intravenously and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=839) or gemcitabine 1250 mg/m2 intravenously on Days 1 and 8 and cisplatin 75 mg/m2 intravenously on Day 1 of each 21-day cycle (n=830)