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Diseases associated with RAGE activation include inflammatory diseases, rheumatic or autoimmune diseases, infectious diseases, diabetes, metabolic syndrome and its complications, obesity, insulin resistance, hypertension, atherosclerosis, neurological diseases such as Alzheimers disease, cardiovascular diseases, pulmonary diseases such as chronic obstructive pulmonary disease (COPD), and cancer.[ref] (Yes, that is pretty much every chronic disease that I can think of and all are associated with aging.) Activation of RAGE (cell membrane receptor) causes an increase in reactive oxygen species as well as an increase in inflammatory cytokines

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