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These models enabled one to investigate acetyl-CoA shifts between mitochondrial and cytoplasmic compartment in pure cholinergic cells under different physiologic and pathogenic conditions (Figs

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On the other hand, the JAK/STAT pathway, activated by cytokines such as IL-6 and interferons, contributes to BBB dysfunction by dimerizing STAT proteins upon activation which translocate to the nucleus, where they regulate the expression of genes involved in inflammation, cell survival, and barrier function