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Pieters with the NASA RELAB facility at Brown University

Research has examined its role in: LHCGR receptor binding, biased agonism, and intracellular cAMP/PKA signalling studies Leydig cell steroidogenesis and testosterone synthesis pathway research HPG axis regulation and gonadotropin interaction studies in male and female models Spermatogenesis, intratesticular testosterone, and male fertility biology research Trophoblast invasion, placentation, and endometrial ECM remodelling investigations Embryo implantation and the embryo-endometrial microenvironment Immune modulation at the maternal-fetal interface regulatory T cells, NK cells, dendritic cells Hyperglycosylated hCG (hCG-H) isoform biology and early pregnancy signalling VEGF-driven angiogenesis and corpus luteum rescue pathway research Comparative LH vs hCG biased agonism and receptor signalling kinetics studies HCG and Corpus Luteum Research Research has shown that rising systemic hCG levels cause a very rapid elevation of serum progesterone, reflecting rescue of the corpus luteum one of hCGs primary endocrine functions

Of the 34 patients with Hunner lesions, although 29/34 (85%) had a successful response, six of these patients stopped the medication for AEs, leaving a final success rate of 68% (23/34)

Also, the study has some limitations, such as the fact that the researchers only used aged female mice for their experiments