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To address this, future interventions should prioritize integrated synbiotic therapies, combining carefully selected probiotics with specific prebiotics to enhance microbial engraftment, stabilize gut ecology, and reinforce host metabolic and immune homeostasis (Balthazar et al., 2022)

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van Lingen RA, Deinum JT, Quak JM et al , Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates