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The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]

It is thought that signals from oxidized lipids and other factors in the vessel wall trigger activation of endothelial cells, resulting in expression of cell surface proteins that attract and adhere to circulating immune cells called monocytes

10.1111/acel.13213 217 WhittingtonH

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