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Paget observed that primary tumor cells of a given type of cancer preferentially metastasized to one or more particular distant organ sites, detectable metastases only developed at those sites (soils) where the tumor cells (seeds) were adapted for survival and proliferation [21]

10.1080/09168451.2017.1364965 69 JohnsonD

Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2)

As we age, there are areas in the brain that become poorly perfused, meaning there is not enough blood flowing through those areas