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Tumour mutational burden LCINS generally have a markedly lower TMB (measured as non-synonymous mutations per megabase (mut/Mb)) in coding and non-coding regions compared to smoking-related lung cancers, with early studies suggesting as much as a tenfold difference 131 and a doseresponse relationship between TMB and pack-years 132 (Table 1)

Neoantigens can be divided into two types: shared neoantigens and personalized neoantigens (Tureci et al., 2018

This process triggers intracellular signaling cascades, leading to increased NLRP3 expression, promotion of myocardial fibrosis, and further acceleration of the progression of atrial fibrillation